Perhaps the better question is how will Juve perform in the Champions League, given the Bianconeri have built their side with a deep run in Europe in mind.
Roma, Inter and Napoli will be hoping the pressure of success and the distraction of midweek games opens the door for them to make a challenge for the Scudetto, as they are the top sides from the chasing pack.
While the Giallorossi lost Pjanic, their recent match against Porto in the Champions League playoff round showed Luciano Spalletti has built a strong outfit that isn't reliant on individual brilliance.
Inter have the formidable trio of Antonio Candreva, Ever Banega and Ivan Perisic, but the feeling is that they wasted valuable time by hiring Frank de Boer late in the summer when it was clear the relationship with previous boss Roberto Mancini was fractured long ago.
Like Roma, Napoli said goodbye to their star man in Higuain, and while names like Emanuele Giaccherini, Piotr Zielinski and Arkadiusz Milik have been brought in, Maurizio Sarri will have to work some magic in order to get the Azzurri past the shock of losing the Argentine.
After those three sides there is quite a gap, with AC Milan starting on the third row. While many would expect to see last season's surprise package Sassuolo there, Vincenzo Montella will see his side strengthened in the winter transfer window once the new Chinese owners can finally invest in the club.
Fiorentina remain a tricky outfit because of Paulo Sousa and his style of play, while will cause the big clubs problems, while Sinisa Mihajlovic finally seems at home at Torino, where his combative nature will meld perfectly with the fighting spirit of the Granata.
Sampdoria, who have looked good in pre-season friendlies, and Genoa will try to finish ahead of Lazio, but the Aquile could surprise many if Ciro Immobile is able to quickly settle in the capital.
The bottom end of the table is always tough to predict, but Crotone appear the favourites to head back down after just one season in the top flight.
Massimo Oddo will try to keep Pescara afloat but the loss of Gianluca Lapadula may prove too much, while Palermo and Maurizio Zamparini will need to keep things relaxed or they run the risk of being relegated.
Empoli are another candidate for the drop, as the signings of Manuel Pasqual and Alberto Gilardino seem out of place for a side that has largely achieved success with youth.
In terms of individual players, expect Higuain to make his mark in Turin and claim the capocannoniere title once again.
Banega, especially given he was signed on a free transfer, will finish the season as the best signing of the summer, while Pjaca will take home the best title of best young player.
Adapted from article in La Gazzetta dello Sport by Sebastiano VernazzaThe post Serie A preview: Juventus and Roma will battle for top prize appeared first on GazzettaWorld.
